Coagulation

Hemostasis Reagents and Controls

Prothrombin Time Assays

Thromboplastin-LI Reagent Kit

Cat. No. / Item / Description

5248 – Thromboplastin-LI Kit, 250 tests – 10 x 5 mL
5249 – Thromboplastin-LI Kit, 500 tests – 10 x 10 mL

Thromboplastin-LI is a stable liquid, ready for use. With a low ISI assignment less than 1.50, this reagent offers reliable sensitivity to liver disease, depression of Vitamin K dependent factors, and coumarin-induced coagulation, even in the presence of high-dose heparin therapy. Open reagent is stable 14 days at 2-8°C.

Activated Partial Thromboplastin Time

aPPT-SA Reagent with Soluble Ellagic Acid Activator

Cat. No. / Item / Description

5388 – aPTT-SA Reagent Kit / 250 tests Ellagic Acid Activated Reagent – 5 x 5 mL / 0.025 M Calcium Chloride – 5 x 5 mL
5389 – aPTT-SA Reagent Kit / 500 tests Ellagic Acid Activated Reagent – 5 x 10 mL 0.025 M Calcium Chloride – 5 x 10 mL
5387 – aPTT-SA Reagent, 1000 tests – 10 x 10 mL
5386 – 0.025 M Calcium Chloride, 1000 tests – 10 x 10 mL

aPTT-SA Reagent uses a soluble ellagic acid activator to provide a more optically clear reagent, an important consideration for automated analyzers with sensitive photo-optical detectors. Ellagic acid reagents also offer excellent precision and sensitivity. aPTT-SA reagent is a stabilized liquid available in three convenient kit sizes.

Fibrinogen and Thrombin Time Assays

Fibrinogen Assay Kit

Cat. No. / Item / Description

5376 – Fibrinogen Assay Kit – 100 tests / Thrombin Reagent – 5 x 2 mL / Fibrinogen Calibrator – 2 x 1 mL / Owren's Veronal Buffer – 2 x 25 mL / Fibrinogen Assay Graph Paper – 1 sheet
5374 – Thrombin Reagent, 200 tests – 10 x 2 mL 0.025 M Calcium Chloride – 5 x 10 mL
5379 –  Fibrinogen Calibrator – 10 x 1 mL

The Fibrinogen Assay kit is for automated, semi-automated and manual quantitation of fibrinogen in plasma. The kit uses a relatively high working concentration of thrombin (100 NIH units/mL) and low fibrinogen concentration to minimize effects of heparin and FDPs. Reagents and calibrator are also available as individual items.

Helena Thrombin Clotting Time (TCT) Reagent

Cat. No. / Item / Description

5377 – Thrombin Time Reagent, 250 tests – 10 x 5 mL

Helena's TCT assay uses a low concentration of thrombin (3 NIH units/mL) with undiluted plasma. It is sensitive to fibrinogen levels below 70 mg/dL. The reagent is ideal for automated, semi-automated and manual instruments.

Factor Deficient Substrates

Congenital Factor Deficient Substrate Plasmas

Cat. No. / Item / Description

5190 – Factor II Deficient Substrate – 10 x 1 mL
5191 – Factor V Deficient Substrate – 10 x 1 mL
5192 – Factor VII Deficient Substrate – 10 x 1 mL
5193 – Factor VIII Deficient Substrate – 10 x 1 mL
5194 – Factor IX Deficient Substrate – 10 x 1 mL
5195 – Factor X Deficient Substrate – 10 x 1 mL
5196 – Factor XI Deficient Substrate – 10 x 1 mL
5197 – Factor XII Deficient Substrate – 10 x 1 mL

For use in Factor Assays, these plasmas are obtained from human congenitally deficient donors (Factor II includes bovine plasma) and have less than 1% residual factor activity.

Owren's Veronal Buffer

Cat. No. / Item / Description

5375 – Owren's Veronal Buffer – 10 x 25 mL

Owren's Veronal Buffer is used as a diluent in preparing patient sample dilutions for Factor Assays and Fibrinogen Assays.

Hemostasis Controls and Reference Plasmas

Hemostasis Controls

Controls for PT, aPTT

Cat. No. / Item / Description

5186 – Norm-Trol 1 – 10 x 1 mL
5187 – Ab-Trol 2 Borderline Control – 10 x 1 mL
5183 – Ab-Trol 3 High Control – 10 x 1 mL

Norm-Trol 1, Ab-Trol 2 and Ab-Trol 3 are normal, moderately elevated, and very elevated controls respectively, for PT and aPTT assays. Norm-Trol 1 is prepared from normal human plasma. Ab-Trol 2 and Ab-Trol 3 are prepared from adsorbed human plasma. Reconstituted controls are stable 8 hours at 2 to 8-C.

S.A.C.-1 and S.A.C.-2 Assayed Controls

Cat. No. / Item / Description

5301 – S.A.C.-1 – 10 x 1 mL
5302 – S.A.C.-2 – 10 x 1 mL

S.A.C.-1 is a normal control plasma assayed for a broad spectrum of hemostasis tests including PT, aPTT, fibrinogen, Proteins C and S, Ristocetin Cofactor, vWF:Ag, plus Factors II, V, VII, VIII, IX, X, XI and XII. S.A.C.-2 is an abnormal control (values < 60% of normal) assayed for the same parameters as S.A.C.-1.

Reference Plasma

S.A.R.P. Specialty Assayed Reference Plasma

Cat. No. / Item / Description

5185 – S.A.R.P. – 10 x 1 mL

Coagulation S.A.R.P. was the first reference plasma fully assayed for virtually all coagulation studies. S.A.R.P. is prepared from a frozen pool of citrated plasma from healthy donors. S.A.R.P. has normal PT and aPTT clotting times and can be used as reference material for the following parameters: