SPIFE Cholesterol Profile

e-Update
Lp(a) Consensus Statement: Screening a Must with Moderate to High CVD Risk

At the EAS 2010 Congress, the European Atherosclerosis Society issued a consensus statement http://www.theheart.org/article/1090493.do recommending lipoprotein(a) screening of patients at moderate or higher cardiovascular disease risk. This comes after two studies in 2009 proved that Lp(a) causes coronary heart disease.

In December 2009, the work of the PROCARDIS Consortium at the University of Oxford was published in the New England Journal of Medicine. They tested nearly 50,000 genetic variants looking for a link to early heart disease and found two ­both strongly associated with increased Lp(a) levels. Their conclusion: Lp(a) is a causal factor in CHD. The June 10, 2009 issue of JAMA included a report from researchers at Copenhagen University. They examined genetic data on over 41,000 people and found that those with the top 10% of Lp(a) had two to three times the risk of heart disease.2

Now the good news: the data also suggest lowering Lp(a) levels will lower the risk of disease.3 The European Atherosclerosis Society recommends patients with an elevated Lp(a) take niacin to reduce their risks. Scientists at Brigham & Women’s Hospital ­ Harvard Medical School measured Lp(a) in nearly 28,000 menopausal women and found those with the highest Lp(a) levels had the highest probability of heart disease. Hormone replacement reduced their Lp(a) and nearly abolished their added risk of CHD. They concluded that Lp(a) and HRT need to be considered in menopausal women.4

Of course, step one is to know your Lp(a) level. The SPIFE Cholesterol method for measuring HDL, LDL, VLDL and Lp(a)-c has proven to be more accurate than mass assays for measuring Lp(a). It isn’t effected by isoform size. SPIFE Cholesterol has the added benefit of a favorable reimbursement margin. SPIFE kits are available for performing up to 100 profiles per gel. Contact Us today to arrange an in-lab SPIFE Cholesterol demonstration and screening.

1. McConnell, et al. Circulation. 2007; 116:II, 818.
2. Clarke, et al. N Engl JMed. 2009; 361: 2518-28.
3. Kamstrup, et al. JAMA. 2009; 301 (22); 2331 ­ 2339.
4. Danik, et al. JACC. 2008; 52: 124-13.

SPIFE Vis Cholesterol Profile Kits

Cat. No.	Item	Description
3438	SPIFE Vis Cholesterol - 100	10 x 100 samples
3439	SPIFE Vis Cholesterol - 80	10 x 80 samples
3440	SPIFE Vis Cholesterol - 60	10 x 60 samples
3441	SPIFE Vis Cholesterol - 40	10 x 40 samples
3442	SPIFE Vis Cholesterol - 20	10 x 20 samples

Kits include: 10 Gels, Cholesterol Reagent, Diluent, Citric Acid Destain, Blotters, and Applicator Blades.

SPIFE Profile Cholesterol

Cat. No.	Item	Description
3218	Cholesterol Profile Control	5 x 1.0 mL

The lyophilized controls are prepared from human plasma and are assayed for HDL, LDL, and VLDL Cholesterol and Lipoprotein(a). Reconstituted controls are stable for 5 days stored at 2 to 8°C. Additional Supplies and Equipment for SPIFE Vis Cholesterol Procedure: SPIFE Reagent Spreader (Cat No. 3386), REP Prep (Cat No. 3100), Gel Block Remover (Cat. No. 1115), Reagent Spreaders for SPIFE 3000 and REP (Cat. No. 3706), SPIFE Disposable Cups - Deep Well (Cat. No. 3360), SPIFE 3000 20-100 Dispo Cup Tray (Cat. No. 3366), SPIFE Disposable Stainless Steel Electrodes (Cat. No. 3388).

 

QuickGel Cholesterol Profile Kit for SPIFE

Cat. No.	Item	Description
3443	QuickGel Cholesterol Kit	10 x 10 samples

Kit includes: 10 QuickGel Cholesterol Gels, Citric Acid Destain, 10 QuickGel Blotters A and C, 20 QuickGel Blotter X, 10 Applicator Blade Assemblies, SPIFE Cholesterol Reagent and SPIFE Cholesterol Diluent. For QuickGel Cholesterol Kit for QuickGel Chamber, see Cat No 3543T.

Cholesterol Profile Control

Cat. No.	Item	Description
3218	Cholesterol Profile Control	5 x 1.0 mL

The lyophilized controls are prepared from human plasma and are assayed for HDL, LDL, and VLDL Cholesterol and Lipoprotein(a). Reconstituted controls are stable for 5 days stored at 2 to 8°C. Additional Supplies and Equipment for SPIFE Vis Cholesterol Procedure: SPIFE Reagent Spreader (Cat No. 3386), REP Prep (Cat No. 3100), Gel Block Remover (Cat. No. 1115), Reagent Spreaders for SPIFE 3000 and REP (Cat. No. 3706), SPIFE Disposable Cups - Deep Well (Cat. No. 3360), SPIFE 3000 20-100 Dispo Cup Tray (Cat. No. 3366), SPIFE Disposable Stainless Steel Electrodes (Cat. No. 3388).